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Curcumin

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Curcumin is a yellow phytonutrient found in turmeric.

Research shows this golden-hued compound has antioxidant and anti-inflammatory activities and may provide protection against several cancers. As an antioxidant, curcumin scavenges free radicals and helps to prevent the oxidation of low-density lipoprotein (LDL)-a key factor in the development of heart disease.

Curcumin is currently being tested in Phase I clinical trials for cancer chemoprevention by the National Cancer Institute.

References

Antunes LMG, Araújo MCP, Darin JD`AC, Bianchi MdeLP. Effects of the antioxidants curcumin and vitamin C on cisplatin-induced clastogenesis in Wistar rat bone marrow cells. Mutat Res. 2000; 465:131-137.Arbiser JL, Klauber N, Rohan R, et al. Curcumin is an in vivo inhibitor of angiogenesis. Mol Med. 1998; 4:376-383.Chan MM-Y. Inhibition of tumor necrosis factor by curcumin, a phytochemical. Biochem Pharmacol. 1995; 49:1551-1556.Huang MT, Newmark HL, Fenkel K. Inhibitory effects of curcumin on tumorigenesis in mice. J Cell Biochem Suppl. 1997; 27:26-34.Kang BY, Song YJ, Kim KM, et al. Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages. BR J Pharmacol. 1999:128:380-384.Kawamori T, Lubet R, Steele VE, et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res. 1999; 59:597-601.Ramiré z-Tortosa MC, Mesa MD, Aguilera MC, et al. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Atherosclerosis. 1999; 147:371-378.

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