Limonoids are phytonutrients found in citrus fruits that help to stimulate detoxification enzymes (including glutathione-S-transferase) in the body.
In lab tests with animals or human cells they have been found to help fight certain cancers including those of the breast, liver, mouth, skin, colon, and lung.
Liminoids may also help lower cholesterol by inhibiting the synthesis of apolipoprotein B, a protein related to high cholesterol.
Manners, G. D., Jacob, R. A., Breksa 3rd, A. P., Schoch, T. K., Hasegawa, S.Bioavailability of citrus limonoids in humans. Journal of Agricultural and Food Chemistry 2003 Jul 2;51(14):4156-4161.Poulose, S. M., Harris, E. D., Patil, B. S. Citrus limonoids induce apoptosis in human neuroblastoma cells and have radical scavenging activity.The Journal of Nutrition 2005 Apr;135(4):870-877. Yu J, Wang L, Walzem RL, Miller EG, Pike LM, Patil BS.Antioxidant activity of citrus limonoids, flavonoids, and coumarins.J Agric Food Chem. 2005 Mar 23;53(6):2009-14.Wood M. Citrus Compound, Ready to Help Your Body!. Agricultural Research, February 2005.